effect of vitamins a, e, c and omega-3 fatty acids on lipid peroxidation in streptozotocin induced diabetic rats

background: to assess the effect of supplementation with vitamins a, e and c and ω-3 fatty acids on lipid peroxidation in strepto zotocin (stz) induced diabetic rats. methods: sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia betic with vitamin a, e as well as c supplementation and diabetic with ω-3 fatty acids supplementation. after four weeks of treat ment the rats were anesthetized and malondialdehyde (mda) levels were investigated in blood samples, liver and heart ho mogenate. results: in diabetic rats mda level in plasma, liver and heart was significantly more elevated than normal control rats (p< 0.05). vitamin a, e and c supplementation caused significant decrease in plasma, liver and heart mda (p< 0.05). a signifi cant decrease in heart mda (p< 0.05) was observed in diabetic rats with ω-3 fatty acids supplementation. conclusion: supplementation of vitamin a, e and c and ω-3 fatty acids was found to decrease lipid peroxidation to some ex tent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.